P754 X-linked inhibitor of apoptosis protein genetic variants in paediatric-onset inflammatory bowel disease

Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells

Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells by Katherine Marie Aird Department of Pathology Duke University Date:_______________________ Approved: ___________________________ Gayathri Devi, Supervisor ___________________________ Mark Dewhirst ___________________________ H. Kim Lyerly ___________________________ Soman Abraham ____...

Endoscopy in Paediatric Inflammatory Bowel Disease (IBD)

The epidemiology of paediatric inflammatory bowel disease.

A retrospective study of the incidence and prevalence of paediatric inflammatory bowel disease over an 11 year period was undertaken in South Glamorgan. Over this time the incidence of Crohn's disease more than doubled from 1.30 cases per 100,000 childhood population per year in the period 1983-1988, to 3.11 cases per 100,000 population per year in the period 1989-1993. In contrast, the inciden...

CEACAM6 Gene Variants in Inflammatory Bowel Disease

BACKGROUND The carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) acts as a receptor for adherent-invasive E. coli (AIEC) and its ileal expression is increased in patients with Crohn's disease (CD). Given its contribution to the pathogenesis of CD, we aimed to investigate the role of genetic variants in the CEACAM6 region in patients with inflammatory bowel diseases (IBD). ME...

Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a common disease, includes Crohn's disease (CD) and ulcerative colitis (UC), and is determined by altered gut bacterial populations and aberrant host immune response. Peptidoglycan recognition proteins (PGLYRP) are innate immunity bactericidal proteins expressed in the intestine. In mice, PGLYRPs modulate bacterial populations in the gut and sensitivity to ex...